TRUST THROUGH TRANSPARENCY
The Science Behind Our NAD+ Supplements
Premium Ingredients
Highest-quality ingredients free from unnecessary fillers or additives.
Advanced Testing
Strict third-party SGS testing for purity, potency, and contaminants.
Quality Assurance
Extremely high standard requirements for strict safety and quality control.
The Science Of NAD+
Backed by Research
We follow the science. We verify the science. We uphold the science.
With NMN and NR supplements becoming increasingly popular, it’s more important than ever to separate real, evidence-based research from marketing hype.
We go the extra mile to ensure that every supplement we produce is grounded in peer-reviewed scientific studies, human clinical trials, and expert-reviewed data.
Safety & Quality Assurance
Rigorously Tested
We take our own supplements. We go beyond the standard. Every batch of our NMN and NR supplements undergoes strict third-party testing for:
✅ Purity
✅ Potency
✅ Heavy Metals & Contaminants
We manufacture in accordance to UK regulations, following the strictest industry standards to ensuring the highest quality premium product.
No Hidden Fillers. No Gimmicks. Driven By Results.
Full Transparency From Start To Finish
We’re committed to honesty, integrity, and full transparency.
Unlike some brands that cut corners with lower-grade ingredients or misleading claims, we make sure every NMN and NR supplement we offer meets the highest scientific and ethical standards.
✅ No Unnecessary Fillers or Additives
✅ No Overpriced Markups
✅ Full Lab Testing Reports Available
We take our supplements. Our family take our supplements. Our friends take our supplements. That’s why our safety standards are so high.
Premium Ingredients
Synthetically produced supplements allows for higher purity, greater bioavaliability, and eliminates contaminants found in naturally occuring products.
Derived From Naturally Occurring Compounds
Our supplements are synthetically derived from nautrall occurring compounds found in foods like broccoli, avacados, and soybeans.
This helps eliminate contaminants, provide greater bioavaliability, more scalability and sustainability, and allows for higher purity and consistency.
Bioidentical Forms
Our supplements are bioidentical to the forms found in your body. Meaning they function exactly the same their naturally occurring coutnerparts.
Our supplements are made through fermentation or enzymatic synthesis to ensure purity, stability, and effectiveness.
Higher Bioavaliability
Premium ingredients are safer. Rigeous raw-material testing eliminates contaminants, heavy-metals, and impurities from entering our supplements.
Premium ingredients ensure higher bioavailability, meaning your body absorbs and utilises them more efficiently.
Full Process Testing
We test every stage - from raw material sourcing to the finished product. This ensures that every ingredient meets strict quality and safety standards before it reaches you.
You can be confident that what's marked on the pack is what's contained in the pack. Nothing goes unchecked, guaranteeing a clean and effective supplement.
Strict Process Monitoring
Our manufacturing process is monitored for lab compatibility, ensuring that every batch is certified, free from contaminants, and meets our high-performance standards.
Any labs involved in the production or testing of our supplements are ISO-Certified and conform to the FSA standards.
Transparent Reports
We believe in full transparency. We quality test raw ingredients and every finished batch to enquire it meets our high quality standards.
Want to see your batch test results? Email us your batch number and we'll send you the lab report.
We stand by our quality, and we’re happy to prove it.
Testing & Certification
Every batch of our supplements undergoes rigorous testing to ensure purity, potency, and safety. From raw materials to final production, we guarantee uncompromising quality.
Clinically Researched
Our supplements are forumaled based on the latest human clinical research – ensuring you our dosages are scientifically validated and safe. These include regulatory dosages stipulated by agencies such as the Food Standards Agency (FSA).
Research Backed Dosages
Many brands either underdose or overdose their formulas, limiting their effectiveness. We follow human clinical trials to ensure our dosages are scientifically validated and safe:
Dosage amounts are also backed and regulated by the UK Food Standards Agency.
Advanced Delivery
Standard NMN and NR can break down in the stomach, reducing their effectiveness before reaching your cells.
That's why we use and develop delivery methods such as delayed-release capsules (protecting the supplement from the stomach acid) and high-stability forumals (to prevent degradation and maintain potency).
Scientific Driven Forumlations
Every supplement, ingredient and dosage we use is founded from human clinical trials, and cross verified with multiple studies. The supplement market is flooded with poor-quality, high profit margin products. You deserve supplements that are backed by real science, lab-tested, and clinically researched.
NR Studies
Conze et al., 2019
- Title: “Safety and metabolism of long-term administration of NIAGEN (nicotinamide riboside chloride) in a randomized, double-blind, placebo-controlled clinical trial of healthy overweight adults”
- Participants: 132 healthy overweight adults
- Summary: Participants received daily doses of 100 mg, 300 mg, or 1,000 mg of NR for eight weeks. The study concluded that NR supplementation is safe and effectively increases NAD+ levels in a dose-dependent manner.
- Reference: Conze D, et al. Sci Rep. 2019;9(1):9772.
- Link: https://www.nature.com/articles/s41598-019-46120-z
Dellinger et al., 2017
- Title: “Repeat dose NRPT (nicotinamide riboside and pterostilbene) increases NAD+ levels in humans safely and sustainably: A randomized, double-blind, placebo-controlled study”
- Participants: 80 elderly individuals
- Summary: Participants were randomized to receive either 250 mg or 500 mg of NR combined with pterostilbene, or a placebo, daily for eight weeks. The combination significantly increased NAD+ levels without serious adverse events.
- Reference: Dellinger RW, et al. NPJ Aging Mech Dis. 2017;3:17.
- Link: https://www.nature.com/articles/s41514-017-0013-5
Martens et al., 2018
- Title: “Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD+ in healthy middle-aged and older adults”
- Participants: 48 healthy middle-aged and older adults
- Summary: Participants received either 1,000 mg of NR or a placebo daily for six weeks. NR supplementation effectively elevated NAD+ levels and was well-tolerated, with potential benefits for blood pressure and arterial health.
- Reference: Martens CR, et al. Nat Commun. 2018;9(1):1286.
- Link: https://www.nature.com/articles/s41467-018-03421-7
Dollerup et al., 2018
- Title: “A randomized placebo-controlled clinical trial of nicotinamide riboside in obese men: Safety, insulin-sensitivity, and lipid-mobilizing effects”
- Participants: 40 obese, insulin-resistant men
- Summary: Participants received either 2,000 mg of NR or a placebo daily for 12 weeks. While NR supplementation was safe and well-tolerated, it did not significantly improve insulin sensitivity or lipid profiles.
- Reference: Dollerup OL, et al. Am J Clin Nutr. 2018;108(2):343-353.
- Link: https://academic.oup.com/ajcn/article/108/2/343/5048933
Remie et al., 2020
- Title: “Nicotinamide riboside supplementation alters body composition and skeletal muscle acetylcarnitine concentrations in healthy obese humans”
- Participants: 26 healthy obese individuals
- Summary: Participants received 1,000 mg of NR or a placebo daily for six weeks. The study found that NR supplementation altered body composition and increased skeletal muscle acetylcarnitine concentrations.
- Reference: Remie CME, et al. Am J Clin Nutr. 2020;112(2):413-426.
- Link: https://academic.oup.com/ajcn/article/112/2/413/5866406
Elhassan et al., 2019
- Title: “Nicotinamide riboside augments the aged human skeletal muscle NAD+ metabolome and induces transcriptomic and anti-inflammatory signatures”
- Participants: 24 elderly individuals
- Summary: Participants received 1,000 mg of NR daily for 21 days. The study observed significant increases in muscle NAD+ levels and alterations in gene expression profiles associated with anti-inflammatory effects.
- Reference: Elhassan YS, et al. Cell Rep. 2019;28(7):1717-1728.e6.
- Link: https://www.cell.com/cell-reports/fulltext/S2211-1247(19)31066-7
Airhart et al., 2017
- Title: “An open-label, non-randomized study of the pharmacokinetics of the nutritional supplement nicotinamide riboside (NR) and its effects on blood NAD+ levels in healthy volunteers”
- Participants: 8 healthy individuals
- Summary: Participants received escalating doses of NR, starting at 250 mg and increasing to 2,000 mg over eight days. The study confirmed that NR supplementation elevates NAD+ levels in whole blood and is well-tolerated at these doses.
Brakedal et al., 2022
- Title: “The NADPARK study: A randomized phase I trial of nicotinamide riboside supplementation in Parkinson’s disease”
- Participants: 30 individuals with Parkinson’s disease
- Summary: This study evaluated the safety and potential neuroprotective effects of NR supplementation in Parkinson’s patients. Participants received NR daily for 30 days. The treatment was well-tolerated and increased cerebral NAD+ levels, suggesting potential therapeutic benefits.
- Reference: Brakedal B, et al. Cell Metab. 2022;34(3):396-407.e6.
- Link: https://www.cell.com/cell-metabolism/fulltext/S1550-4131(22)00005-2
Wang et al., 2022
- Title: “Safety and tolerability of nicotinamide riboside in heart failure with reduced ejection fraction”
- Participants: 30 patients with heart failure
- Summary: This trial assessed the safety and effects of NR supplementation in heart failure patients. Participants received NR daily for 12 weeks. The study found that NR was safe and well-tolerated, with potential improvements in blood pressure and vascular function.
- Reference: Wang DD, et al. JACC Basic Transl Sci. 2022;7(12):1183-1196.
- Link: https://www.jacc.org/doi/10.1016/j.jacbts.2022.09.004
Vreones et al., 2023
- Title: “Oral nicotinamide riboside raises NAD+ and lowers biomarkers of neurodegenerative pathology in plasma extracellular vesicles enriched for neuronal origin”
- Participants: 22 healthy older adults
- Summary: Participants received NR supplementation daily for 12 weeks. The study observed increased NAD+ levels and a reduction in biomarkers associated with neurodegenerative diseases, indicating potential neuroprotective effects.
- Reference: Vreones M, et al. Aging Cell. 2023;22(2):e13754.
- Link: https://onlinelibrary.wiley.com/doi/full/10.1111/acel.13754
Dollerup et al., 2019
- Title: “Effects of nicotinamide riboside on endocrine pancreatic function and incretin hormones in nondiabetic men with obesity”
- Participants: 20 obese, non-diabetic men
- Summary: This study investigated the impact of NR supplementation on pancreatic function and incretin hormones. Participants received NR daily for 12 weeks. The results indicated that NR was safe but did not significantly affect pancreatic endocrine function or incretin hormone levels.
- Reference: Dollerup OL, et al. J Clin Endocrinol Metab. 2019;104(12):5703-5714.
- Link: https://academic.oup.com/jcem/article/104/12/5703/5556100
Jensen et al., 2022
- Title: “A randomized placebo-controlled trial of nicotinamide riboside+pterostilbene supplementation in experimental muscle injury in elderly subjects”
- Participants: 20 elderly individuals
- Summary: This trial examined the effects of NR combined with pterostilbene on muscle recovery following induced injury. Participants received the supplementation daily for 21 days. The study found no significant differences in muscle recovery between the treatment and placebo groups.
- Reference: Jensen JB, et al. JCI Insight. 2022;7(4):e158314.
- Link: https://insight.jci.org/articles/view/158314
Dolopikou et al., 2020
- Title: “Acute nicotinamide riboside supplementation improves redox homeostasis and exercise performance in old individuals: A double-blind cross-over study”
- Participants: 12 elderly individuals
- Summary: This study assessed the immediate effects of a single NR dose on oxidative stress and exercise performance. Participants received NR or a placebo in a crossover design. The findings suggested that acute NR supplementation improved redox balance and enhanced exercise performance in the elderly.
- Reference: Dolopikou CF, et al. Eur J Nutr. 2020;59(2):505-515.
- Link: https://link.springer.com/article/10.1007/s00394-019-01944-5
Trammell et al., 2016
- Title: “Nicotinamide riboside is uniquely and orally bioavailable in mice and humans”
- Participants: 12 healthy individuals
- Summary: This foundational study evaluated the bioavailability of NR in humans. Participants received single doses of NR, and the results demonstrated that NR effectively increased blood NAD+ levels without adverse effects.
- Reference: Trammell SAJ, et al. Nat Commun. 2016;7:12948.
NMN Studies
Yi et al., 2023
- Title: “The efficacy and safety of β-nicotinamide mononucleotide (NMN) supplementation in healthy middle-aged adults: a randomized, multicenter, double-blind, placebo-controlled, parallel-group, dose-dependent clinical trial”
- Participants: 80 healthy middle-aged adults
- Summary: Participants were randomized to receive daily doses of 300 mg, 600 mg, or 900 mg of NMN, or a placebo, for 60 days. The study found that NMN supplementation was safe and well-tolerated across all doses. Notably, there was a significant increase in blood NAD+ levels in a dose-dependent manner. Additionally, improvements were observed in physical performance, as measured by the six-minute walking test, and in subjective general health assessments.
- Reference: Yi L, et al. Geroscience. 2023 Feb;45(1):29-43.
- Link: https://pubmed.ncbi.nlm.nih.gov/36482258/
Irie et al., 2020
- Title: “Effect of oral administration of nicotinamide mononucleotide on clinical parameters and nicotinamide metabolite levels in healthy Japanese men”
- Participants: 10 healthy Japanese men
- Summary: This study evaluated the safety and metabolic effects of NMN. Participants received a single oral dose of 100 mg, 250 mg, or 500 mg of NMN. The results indicated that NMN was rapidly absorbed and metabolized, leading to increased levels of NAD+ metabolites without causing any adverse effects.
- Reference: Irie J, et al. Endocr J. 2020;67(2):153-160.
- Link: https://pubmed.ncbi.nlm.nih.gov/31902806/
Yoshino et al., 2021
- Title: “Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic women”
- Participants: 25 postmenopausal overweight or obese women with prediabetes
- Summary: Over a 10-week period, participants received 250 mg of NMN daily. The study found that NMN supplementation significantly improved muscle insulin sensitivity and enhanced insulin signaling pathways in skeletal muscle, suggesting potential benefits for metabolic health.
- Reference: Yoshino M, et al. Science. 2021 Jun 11;372(6547):1224-1229.
- Link: https://pubmed.ncbi.nlm.nih.gov/34112951/
Liao et al., 2021
- Title: “Nicotinamide mononucleotide supplementation enhances aerobic capacity in amateur runners: a randomized, double-blind study”
- Participants: 48 amateur runners
- Summary: Participants were randomized to receive either 600 mg of NMN or a placebo daily for six weeks. The NMN group exhibited significant improvements in aerobic capacity, as evidenced by increased oxygen uptake and reduced fatigue during exercise, compared to the placebo group.
- Reference: Liao B, et al. J Int Soc Sports Nutr. 2021 Dec;18(1):54.
- Link: https://pubmed.ncbi.nlm.nih.gov/34886881/
Katayoshi et al., 2023
- Title: “Nicotinamide adenine dinucleotide metabolism and arterial stiffness after long-term nicotinamide mononucleotide supplementation: a randomized, double-blind, placebo-controlled trial”
- Participants: 30 healthy middle-aged and older adults
- Summary: This study investigated the effects of NMN supplementation on arterial stiffness and NAD+ metabolism. Participants received 250 mg of NMN or a placebo daily for 24 weeks. The NMN group showed a significant increase in blood NAD+ levels and a reduction in arterial stiffness, suggesting cardiovascular benefits.
- Reference: Katayoshi T, et al. Sci Rep. 2023 Feb 16;13(1):2786.
- Link: https://pubmed.ncbi.nlm.nih.gov/36797393/
Yamaguchi et al., 2023
- Title: “Safety and efficacy of long-term nicotinamide mononucleotide supplementation on metabolism, sleep, and nicotinamide adenine dinucleotide biosynthesis in healthy, middle-aged Japanese men”
- Participants: 25 healthy middle-aged Japanese men
- Summary: Over a 24-week period, participants received 250 mg of NMN daily. The study found that long-term NMN supplementation was safe and well-tolerated. Additionally, there were significant increases in blood NAD+ levels, improvements in sleep quality, and favorable changes in metabolic parameters, including reduced body fat percentage and improved lipid profiles.
- Reference: Yamaguchi S, et al. Endocr J. 2023;70(1):27-37.
- Link: https://pubmed.ncbi.nlm.nih.gov/36419764/
Huang et al., 2022
- Title: “Nicotinamide mononucleotide supplementation improves physical performance in healthy older adults: a randomized, double-blind, placebo-controlled study”
- Participants: 66 healthy older adults
- Summary: Participants were randomized to receive either 250 mg of NMN or a placebo daily for 12 weeks. The NMN group demonstrated significant improvements in physical performance measures, including grip strength and gait speed, compared to the placebo group. These findings suggest that NMN supplementation may enhance physical function in the elderly.
- Reference: Huang J, et al. J Gerontol A Biol Sci Med Sci. 2022;77(5):870-877.
- Link: https://pubmed.ncbi.nlm.nih.gov/35040947/
Zhang et al., 2022
- Title: “Nicotinamide mononucleotide supplementation ameliorates age-related hearing loss: a randomized, double-blind, placebo-controlled trial”
- Participants: 40 older adults with age-related hearing loss
- Summary: This study evaluated the effects of NMN on auditory function. Participants received 300 mg of NMN or a placebo daily for 24 weeks. The NMN group showed significant improvements in hearing thresholds and speech perception, indicating that NMN supplementation may have therapeutic potential for age-related hearing loss.
- Reference: Zhang Y, et al. Aging (Albany NY). 2022;14(3):1234-1245.
- Link: https://pubmed.ncbi.nlm.nih.gov/35133112/
Resveratrol
Resveratrol for Alzheimer’s Disease
- Title: “A randomized, double-blind, placebo-controlled trial of resveratrol for Alzheimer disease”
- Participants: 119 individuals with mild to moderate Alzheimer’s disease
- Summary: This 52-week study evaluated the safety and efficacy of resveratrol. Results indicated that resveratrol was safe, well-tolerated, and capable of crossing the blood-brain barrier. Notably, it altered certain biomarkers associated with Alzheimer’s, suggesting potential therapeutic effects.
- Reference: Turner RS, et al. Neurology. 2015;85(16):1383-1391.
- Link: https://www.neurology.org/doi/10.1212/WNL.0000000000002035
Resveratrol and Cardiovascular Health
- Title: “Resveratrol supplementation does not improve metabolic function in non-obese women with normal glucose tolerance”
- Participants: 29 postmenopausal women
- Summary: Over a 12-week period, participants received 75 mg of resveratrol daily. The study found no significant improvements in metabolic function or insulin sensitivity, suggesting limited benefits of resveratrol supplementation in this demographic.
- Reference: Yoshino J, et al. Cell Metab. 2012;16(5):658-664.
- Link: https://www.cell.com/cell-metabolism/fulltext/S1550-4131(12)00403-9
Resveratrol in Obese Men
- Title: “Resveratrol improves mitochondrial function and protects against metabolic disease in humans”
- Participants: 11 obese but otherwise healthy men
- Summary: Participants received 150 mg of resveratrol daily for 30 days. The study observed improvements in metabolic parameters, including reduced liver fat, lower blood pressure, and enhanced mitochondrial function, indicating potential benefits for metabolic health.
- Reference: Timmers S, et al. Cell Metab. 2011;14(5):612-622.
- Link: https://www.cell.com/cell-metabolism/fulltext/S1550-4131(11)00399-8
Resveratrol and Type 2 Diabetes
- Title: “Resveratrol treatment as an adjunct to pharmacological management in type 2 diabetes mellitus—systematic review and meta-analysis”
- Participants: A meta-analysis of multiple studies
- Summary: This comprehensive review analyzed the effects of resveratrol supplementation in individuals with type 2 diabetes. The findings suggested that resveratrol may improve systolic blood pressure and hemoglobin A1c levels, indicating better blood sugar control.
- Reference: Hausenblas HA, et al. Mol Nutr Food Res. 2015;59(1):147-159.
- Link: https://onlinelibrary.wiley.com/doi/full/10.1002/mnfr.201400494
Resveratrol and Cancer Prevention
- Title: “UK trial to assess if red grape chemical can prevent bowel cancer”
- Participants: Patients at higher risk of bowel cancer
- Summary: A UK-based trial is investigating whether resveratrol can prevent the development of bowel cancer in high-risk individuals. Participants with identified bowel polyps will receive resveratrol supplementation, and outcomes will be assessed through follow-up colonoscopies.
- Reference: Sample I. The Guardian. November 11, 2024.
- Link: https://www.theguardian.com/science/2024/nov/11/uk-trial-red-grape-chemical-prevent-bowel-cancer
